中文摘要：

Sphingosine-1-phosphate (S1P ) 是在通过未知机制调整基因表示和 NF-KB 信号小径的房间的一个 bioactive 类脂化合物送信人。最近，在 Materia Medica 的上海研究所的 DDDC 的副教授罗成，其工程被中国的国家自然科学基金会资助，加入弗吉尼亚共同体的莎拉·斯皮吉尔教授领导的一个研究队大学。队连续地在理解 Sphingosine-1-Phosphate 的规定机制做了重要突破。在 2009 年 9 月，在科学上在一篇论文出版了杂志(科学 2009， 325：1254-7 ) ，他们第一证明 S1P 是 histone deacetylases (HDAC ) 的一个生理地重要的管理者， HDAC 是 S1P 的直接细胞内部的目标。而且，他们识别了 S1P 调整的机制通过调整 HDAC 的活动的基因表示。在 2010 年 6 月 24 日，在另外一个糊在自然杂志上被出版(自然 2010， 6 月 24 日，推进联机出版) 它报导由 S1P 表明小径的 NF-KB 的规定。他们证明 S1P 是为 TRAF2 的失踪的余因子(瘤坏死因素联系受体的因素 2 ) 并且为 lysine-63-linked poly-ubiquitination 的规定显示一个新范例。学习也在 TNF- 发信号和正规 NF-KB 激活小径加亮 SphK1 和它的产品 S1P 的关键角色，然后起关键作用在煽动性， antiapoptotic 和有免疫力的过程。S1P 由调整基因表示和 TNF 和 NF-KB 发信号小径的新机制的鉴定将照亮道路开发可能为癌症和煽动性的疾病的治疗有用的新奇禁止者。

英文摘要：

Sphingosine-1-phosphate（S1P） is a bioactive lipid messenger in the cells that regulate gene expression and NF-κB signal pathway through unknown mechanisms.Recently,Cheng Luo,associate professor of DDDC in Shanghai Institute of Materia Medica,whose project was funded by the National Natural Science Foundation of China,joined in a research team led by Professor Sarah Spiegel of Virginia Commonwealth University.The team continuously made significant breakthroughs in understanding the regulation mechanism of Sphingosine-1- Phosphate.In September 2009,in a paper published on SCIENCE magazine（Science 2009, 325：1254-7）,they firstly demonstrated that S1P is a physiologically important regulator of histone deacetylases（HDACs）,HDACs are direct intracellular targets of S1P.Furthermore,they identified the mechanism that S1P regulates gene expression through regulating the activity of HDACs.In June 24th,2010,in another paper to be published on NATURE magazine（Nature 2010,June 24th,advance online publication,（doi：10.1038/ nature09128）） which reports the regulation of NF-κB signaling pathway by S1P.They demonstrate that S1P is the missing cofactor for TRAF2（tumour-necrosis factor receptor-associated factor 2） and indicate a new paradigm for the regulation of lysine-63- linked poly-ubiquitination.The study also highlight the key role of SphK1 and its product S1P in TNF-αsignalling and the canonical NF-κB activation pathway, and then play crucial role in inflammatory,antiapoptotic and immune processes.The identification of new mechanisms fay which S1P regulates gene expression and TNF and NF-κB signaling pathway will light up the road to develop novel inhibitors that might be useful for treatment of cancer and in- flammatory diseases.