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Computational drug discovery
  • ISSN号：1671-4083
  • 期刊名称：Acta Pharmacologica Sinica
  • 时间：0
  • 页码：1131-1140
  • 分类：R914[医药卫生—药物化学;医药卫生—药学]
  • 作者机构：[1]第四军医大学药学院药物化学与药物分析学教研室,陕西西安710032, [2]中国科学院上海药物研究所新药研究国家重点实验室药物发现与设计中心,上海201203
  • 相关基金：国家自然科学基金项目（91029704）;广东省科技计划项目（2010A030100006）
  • 相关项目：靶向B-Raf激酶V600E突变体的抗肿瘤药物先导化合物的优化研究
作者： Si-sheng Ou-Yang|Jun-yan Lu|Xiang-qian Kong|Zhong-jie Liang| Cheng Luo|Hualiang Jiang|
关键词： 糖尿病, 表观遗传学, DNA甲基化酶, 抑制剂, diabetes mellitus, epigenetics, DNMT, inhibitor
中文摘要：

肥胖和糖尿病是常见的代谢性疾病，严重危害人类健康。尽管经过几十年的持续研究，但人们对于肥胖与糖尿病发病的遗传基础和分子机制仍然知之甚少。近来研究发现，表观遗传学可以通过多种机制将环境影响与许多疾病的发生发展过程联系起来。某些特定基因的表观遗传修饰的改变可能是导致糖尿病和肥胖的始动因素。在本文中，作者首先阐述肥胖和糖尿病的主要致病机制，并对相关靶标蛋白及其小分子抑制剂进行介绍，从而对揭示表观遗传修饰的改变诱发肥胖和糖尿病的分子机制做一个总结，为相关疾病的防治提供线索。

英文摘要：

Diabetes and obesity are commonly found among metabolic disorders affect patients worldwide. Till now, efforts have been done by researchers for decades. However, the genetic basis and molecular mechanisms were still ambiguous. Recent researchers have claimed the correlations between epigenetic changes and multiple environmental factors which involved in occurrence and development of diabetes and obesity. Epigenetic changes of certain genes may serve as the starting factors of developing diabetes and obesity. In this paper, we summarized those epigenetic targets and their inhibitors which are potentially involved for the obesity and diabetes, and then provided a few clues for preventing and treating these syndromes.

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靶向B-Raf激酶V600E突变体的抗肿瘤药物先导化合物的优化研究
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药物作用新靶标、新机制和新分子实体发现方法与应用研究
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期刊信息
  • 《中国药理学报：英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中科院上海药物研究所
  • 主编：丁光生
  • 地址：上海市太原路294号31号楼
  • 邮编：200031
  • 邮箱：
  • 电话：021-54922821 54922822
  • 国际标准刊号：ISSN：1671-4083
  • 国内统一刊号：ISSN：31-1347/R
  • 邮发代号:4-295
  • 获奖情况:
  • 1992、1996年两届全国优秀科技期刊一等奖,1992、1996、1997年中国科协、中科院以及上海市优...,首届国家期刊奖、2000年中科院优秀期刊评比特别奖
  • 国内外数据库收录:
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  • 被引量:1239