中文摘要：

介绍了单片集成MEA系统和用于该系统的神经元信号探测电路和激励电路，基本单元电路是低功耗、低噪声、高增益和小版图尺寸的运算放大器．详细讨论了探测电路、激励电路和基本单元运算放大器的设计．神经元信号探测电路版图面积290μm×400μm，功耗2．02mw，等效输入噪声17．72nV／Hz，增益60．5dB，输出电压摆幅-2．48～＋2．5V．激励电路版图面积130μm×290μm，功耗740μW，输出电压摆幅～2．5～2．04V．参数表明这2种电路适用于单片集成MEA系统．探测电路和单片集成MEA系统已经流片．探测电路的测试结果表明电路工作正常．

英文摘要：

A neuronal signal detecting circuit and a neuronal signal stimulating circuit designed for a monolithic integrated MEA（micro-electrode array） system are described. As a basic cell of the circuits, an OPA（ operational amplifier） is designed with low power, low noise, small size and high gain. The detecting circuit has a chip area of 290 μm × 400 μm, a power dissipation of 2.02 mW, an equivalent input noise of 17.72 nV/ Hz, a gain of 60. 5 dB, and an output voltage from - 2. 48 to ＋ 2. 5 V. The stimulating circuit has a chip area of 130 μm × 290 μm, a power dissipation of 740 μW, and an output voltage from - 2. 5 to 2. 04 V. The parameters show that two circuits are suitable for a monolithic integrated MEA system. The detecting circuit and MEA have been fabricated. The test results show that the detecting circuit works well.