中文摘要：

目的 应用倾向指数方法,观察肾康注射液治疗慢性肾功能衰竭的疗效。方法 随机选择2200例慢性肾功能衰竭患者接受治疗,注射肾康注射液,疗程4周。应用倾向指数匹配法后,剂量60 ml组和剂量100 ml组共665例患者,以中心作为随机效应,建立非线性混合效应模型进行疗效评估。结果 在均衡了体重指数、病情分级等重要预后因素后,剂量60 ml和剂量100 ml组在慢性肾功能衰竭疗效方面差异无统计学意义。结论 肾康注射液治疗慢性肾功能衰竭疗效确切,剂量60 ml和剂量100 ml疗效相当。

英文摘要：

Objective To verify the efficacy of Shenkang injection on patients with chronic renal failure. Methods 2200 patients with chronic renal failure were recruited and received Shenkang injection between the dosage of 60 ml and 100 ml once dally for 4 weeks： Using propensity score for dosage, we were able to match 665 patients with dosage of 60 ml or 100 ml. We constructed nonlinear mixed model regarding center as random effect to assess the efficacy. Results There is no significance difference between the dosage of 60 ml and 100 ml in the efficacy of chronic renal failure. Conclusion Shenkang injection is a valid treatment in chronic renal failure. The dosage of 60 ml is similar with the dosage of 100 ml in efficacy.