中文摘要：

目的：探讨精神分裂症急性期患者5-羟色胺转运体（SERT）mRNA表达水平及其与临床因素的关系。方法：收集44例未经治疗的精神分裂症急性期患者的临床资料,给予阳性与阴性症状量表（PANSS）评估;采用逆转录聚合酶链反应（RT-PCR）方法测定外周血SERT mRNA表达。结果：有攻击行为患者（26例）SERT mRNA表达明显高于无攻击行为患者（18例）（F=9.75,P〈0.01）。SERT mRNA表达与患者发病年龄无相关（r=0.056,P=0.722）;与病程呈正相关（r=0.418,P〈0.01）;与PANSS的阴性症状分呈负相关（r=-0.335,P〈0.05）;与PANSS总分、阳性症状分及一般精神病理分无相关性（r=-0.156,P=0.317;r=0.115,P=0.465;r=-0.097,P=0.538）。结论：精神分裂症急性期患者SERT mRNA高表达与其病程长、伴有攻击行为以及阴性症状量表评分低有关。

英文摘要：

Objective： To explore the correlations between serotonin transporter （SERT） mRNA expres- sion and clinical factors in schizophrenic patients at acute phase. Method：The clinical data of 44 untreated schizophrenic patients at acute phase were collected; and they were assessed by positive and negative syndromes scales （PANSS） ; the expression of SERT mRNA of peripheral blood was detected by reverse transcriptase poly- merase chain reaction （RT-PCR）. Results：The expression of SERT mRNA in the patients with aggressive be- havior （26 cases） was significantly higher than the patients without aggressive behavior （ 18 cases） （ F =9. 75, P 〈 0.01 ）. The expression of SERT mRNA was not correlated with age of onset （ r = 0. 056 ,P = 0. 722 ）, posi- tively correlated with the course of disease （r = 0. 418, P 〈 0.01 ） ; negatively correlated with negative symptom score of PANSS（ r = - 0. 335,P 〈 0.05 ）, but not correlated with the total score of PANSS, scores of positive symptoms and general psychopathology （r = -0. 156,P =0. 317;r =0. I15,P =0. 465;r = -0.097,P = 0. 538 ）. Conclusion： The high expression of SERT mRNA in schizophrenic patients at acute phase is asso- ciated with longer duration, aggressive behavior and lower seore of negative symptoms scale.