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首发未治精神分裂症患者利培酮治疗前后血浆IL-6、IL-10、IL-12水平变化
  • ISSN号:1002-266X
  • 期刊名称:山东医药
  • 时间:2013
  • 页码:68-69
  • 分类:R394[医药卫生—医学遗传学;医药卫生—基础医学]
  • 作者机构:[1]首都医科大学附属北京安定医院抑郁症治疗中心,北京100088, [2]国家精神心理疾病临床医学研究中心(首都医科大学附属北京安定医院), [3]北京市怀柔安佳医院, [4]精神疾病诊断与治疗北京市重点实验室, [5]北京脑重大疾病研究院抑郁症研究所
  • 相关基金:重大新药刨制科技重大专项(2012ZX09303014-002);国家自然科学基金面上项目(81171269);北京市教委面上项目(SQKM201210025021)
  • 相关项目:5-HT转运体(SERT)mRNA表达与精神分裂症发病机制及疗效机制的研究
中文摘要:

治未病是指采取预防或治疗手段防止疾病发生、发展。根据每个人的健康状况不同,采取相应的个体化预防方案进行治未病,是古今中外医学界不断追求的梦想。如今,在中关村这一梦想正在变为现实。

英文摘要:

Objective: To study the differences of serotonin transporter ( SERT ) mRNA expression levels in peripheral leukocytes between acute phase of schizophrenia patients and healthy control. To study the gender differences in the SERT mRNA expression levels between two goUps. Method: 44 patients with acute phase of schizophrenia were selected in our hospital from May 2013 to November 2013, and then 42 healthy cases with the same age and gender were selected as the control group. The diagnosis of schizophrenia was established according to the DSM-IV-TR criteria. The severity of schizophrenia was assessed by the positive and negative syndromes scales ( PANSS ) .All subjects were interviewed using self-designed questionnaire on general information and tested by quantitative real-time PCR method in SERT mRNA levels.Result: SERT mRNA levels in leukecytes in acute phase of schizophrenia patients were significantly higher than that in control group, the difference was statistically significant ( P〈0.05 ) .Compared the SERT mRNA levels of two groups'gender, the difference was no statistically significant ( P〉0.05 ) . Conclusion: The over expression of SERT mRNA levels may be one of the biomarkers of schizophrenia in acute phase.

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期刊信息
  • 《山东医药》
  • 北大核心期刊(2014版)
  • 主管单位:山东省卫生和计划生育委员会
  • 主办单位:山东卫生报刊社
  • 主编:邱源
  • 地址:济南市燕东新路6号山东卫生报刊社
  • 邮编:250014
  • 邮箱:sdyy88516158@163.com
  • 电话:0531-88957404
  • 国际标准刊号:ISSN:1002-266X
  • 国内统一刊号:ISSN:37-1156/R
  • 邮发代号:24-8
  • 获奖情况:
  • 2009年第四届华东地区优秀期刊、2000年山东省自然...
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,美国剑桥科学文摘,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:98858