中文摘要：

报道了一种基于Dehydro—α—curcumene（4）为关键中间体，以Sharpless不对称双羟化反应和碘催化的分子内环化成醚反应为关键步骤，构建2，2，5位三取代的四氢呋喃骨架的方法，完成了（7R，10S）-Boivinianin B（1）的不对称合成．合成路线简捷，对此类化合物的合成有一定的借鉴意义．

英文摘要：

（7R, 10S）-Boivinianin B （1）, a naturally occurring sesquiterpene which has a synthetically challenging 2,2,5-tri-substituted tetrahydrofuran skeleton, was isolated from Laurencia tristicha and Cipadessa boiviniana. First asymmetric synthesis of the title compound was developed by sharpless asymmetric dihydroxyation to generate a stereocenter which as a chiral pool in the next procedure and an intramolecular iodoetherification to construct the tetrahydrofuran skeleton. The method developed here will be a useful tool for the stereoselective synthesis of 2,2,5-tri-substituted tetrahydrofurans bearing sterically congested benzylic quaternary center.