中文摘要：

目的 分析不同年龄组促排卵周期夫精宫腔内人工授精（IUI）的临床结局及其影响因素.方法 回顾性分析2008年1月至2015年12月期间在海南医学院第一附属医院生殖中心进行促排卵周期IUI治疗的4228个周期的临床资料,分析临床妊娠率、抱婴率、流产率与女性年龄的关系.结果 IUI临床妊娠率为14.5％（614/4228）,抱婴率为10.1％（429/4228）,流产率为15.5％（95/614）;按照女性年龄分为21～25岁组、26～30岁组、31～35岁组、36～38岁组、39～40岁组、〉40岁组,各组临床妊娠率依次分别为16.5％（40/242）、16.8％（262/1559）、14.2％（224/1578）、13.1％（59/451）、8.9％（18/203）、5.6％（11/195）;其抱婴率依次分别为10.3％（25/242）、12.2％（190/1559）、10.2％（161/1578）、8.4％（38/451）、4.9％（10/203）、2.6％（5/195）;其流产率依次分别为7.5％（3/40）、14.1％（37/262）、13.4％（30/224）、25.4％（15/59）、27.8％（5/18）、45.5％（5/11）;各年龄组临床妊娠率、抱婴率、流产率比较差异均有显著统计学意义（P〈0.01）;HCG日子宫内膜厚度平均（9.4±2.0）mm,各组的子宫内膜厚度比较差异无统计学意义（P〉0.05）;各组平均处理后前向运动精子数依次分别是（11.7±12.3）百万、（10.4±10.8）百万、（9.9±9.4）百万、（10.2±10.6）百万、（8.9±10.0）百万,各组比较差异均无统计学意义（P〉0.05）;各组的不孕年限依次分别为（3.5±1.5）年、（4.3±2.1）年、（5.2±2.7）年、（6.3±3.8）年、（6.3±4.6）年、（6.2±5.2）年;IUI次数依次分别为（1.4±0.6）次、（1.5±0.8）次、（1.6±0.8）次、（1.6±0.8）次、（1.6±0.9）次、（1.7±1.2）次;直径≥14 mm卵泡个数依次分别为（2.8±2.1）个、（2.7±2.1）个、（2.5±1.9）个、（2.5±1.8）个、（2.4±1.6）个、（2.3±1.4）个;不孕年限、IUI次数、直径≥14 mm的卵泡个数总体分布不全相同,差?

英文摘要：

Objective To investigate the effect of women＆#39;s age on the pregnancy outcomes of intrauterine in-semination with husband＆#39;s sperm in ovulation-promoting cycle. Methods The clinical data of 4228 ovulation-promot-ing cycles of intrauterine insemination with the husband＆#39;s sperm which performed in the Reproductive Center of the First Affiliated Hospital of Hainan Medical University from January 2008 to December 2015 were collected and retrospective-ly analyzed. The correlations between clinical pregnancy rate, delivery rate, miscarriage rate and women＆#39;s age were ana-lyzed. Results The overall clinical pregnancy rate, delivery rate and miscarriage rate were 14.5%（614/4228）, 10.1%（429/4228）, and 15.5%（95/614）, respectively. According to the women＆#39;s age, the cycles were divided into the follow-ing groups：21-25 years group, 26-30 years group, 31-35 years group, 36-38 years group, 39-40 years group, over 40 years group. The clinical pregnancy rates of the different age groups were 16.5%（40/242）, 16.8%（262/1559）, 14.2%（224/1578）, 13.1% （59/451）, 8.9% （18/203） and 5.6% （11/195）, respectively; the delivery rates were 10.3% （25/242）, 12.2%（190/1559）, 10.2%（161/1578）, 8.4%（38/451）, 4.9%（10/203） and 2.6%（5/195）, respectively;the abortion rates were 7.5% （3/40）, 14.1% （37/262）, 13.4% （30/224）, 25.4% （15/59）, 27.8% （5/18）, 45.5% （5/11）, respectively. There were statistically significant differences in the clinical pregnancy rate, delivery rate and miscarriage rate between the dif-ferent age groups （P〈0.01）. The average endometrial thickness of HCG day was （9.4±2.0） mm, and there was no statisti-cal difference in the endometrial thickness between the different age groups （P〉0.05）. The average progressive sperms＆#39; count （millions） of the different age groups were （11.7 ± 12.3） millions, （10.4 ± 10.8） millions, （9.9 ± 9.4） millions, （10.2 ± 10.6） millions, （8.9±10.0） mil