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Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques （Macaca leonina）

ISSN号：2095-8137
期刊名称：《动物学研究》
时间：0
分类：S829.2[农业科学—畜牧学;农业科学—畜牧兽医] TS251.93[轻工技术与工程—农产品加工及贮藏工程;轻工技术与工程—食品科学与工程]
作者机构：[1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China, [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China, [3]Department of Clinical Laboratory, the Second Hospital of Yunnan Province, Kunming, Yunnan 650021, China, [4]Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
相关基金：Foundation items： This work was supported by the National Natural Science Foundation of China （81172876, U0832601, 81273251, U1202228）; the National Special Science Research Program of China （2012CBA01305）; the National Science and Technology Major Project （2013ZX10001-002, 2012ZX10001-007） and the Knowledge Innovation Program of CAS （KSCX2-EW-R-13）.

作者： Xiao-Liang ZHANG[1,2], Wei PANG[2], De-Yao DENG[3], Long-Bao LV[4], Yue FENG[1], Yong-Tang ZHENG[2,4]

关键词：血清免疫球蛋白, 补体C3, CRP, 猕猴, 酒店, 圈养, IgM抗体, 全自动生化分析仪, Northern pig-tailed macaque （Macaca leonina）, Immunoglobulin, Complement, C-reactive protein

中文摘要：

The northern pig-tailed macaque(NPM,Macaca leonina) has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3-11 year old captive northern pig-tailed macaques using HITACHI 7600-20 automated chemistry analyzer in order to determine the influences of age and gender on these items. The results showed that serum IgA, IgM, C3 and C4 levels were not correlated with age(P>0.05), while serum IgG levels increased progressively with age(r=0.202;P=0.045). Serum IgG, IgA, IgM and C3 levels were higher in females than in males(P<0.05). Moreover, serum C3 concentration was both positively and strongly correlated with that of C4(r=0.700; P<0.0001). This study provides basic serum immunoglobulin and complement data of captive northern pig-tailed macaques, which may prove useful for future breeding efforts and biomedical research.

英文摘要：

The northem pig-tailed macaque （NPM, Macaca leonina） has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3-11 year old captive northem pig-tailed macaques using HITACHI 7600-20 automated chemistry analyzer in order to determine the influences of age and gender on these items. The results showed that serum IgA, IgM, C3 and C4 levels were not correlated with age （P〉0.05）, while serum IgG levels increased progressively with age （r=0.202; P=0.045）. Serum IgG, IgA, IgM and C3 levels were higher in females than in males （P〈0.05）. Moreover, serum C3 concentration was both positively and strongly correlated with that of C4 （r=0.700; P〈0.0001）. This study provides basic serum immunoglobulin and complement data of captive northem pig-tailed macaques, which may prove useful for future breeding efforts and biomedical research.