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Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress
  • ISSN号:2095-8137
  • 期刊名称:《动物学研究》
  • 时间:0
  • 分类:Q959.848[生物学—动物学] Q987[生物学—遗传学;生物学—人类学]
  • 作者机构:[1]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China, [2]Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China, [3]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming Yunnan 650500, China
  • 相关基金:This work was supported by the National Natural Science Foundation of China (81172876, 81273251, U1202228, 81471620); the National Special Science Research Program of China (2012CBA01305); the National Science and Technology Major Project (2013ZX10001-002, 2012ZX10001-007) and the Knowledge Innovation Program of CAS (KSCX2-EW-R-13, KJZD-EW-L10-02) The opinions expressed in this review paper reflect personal views of the authors. Due to the limited space of this paper and/or our ignorance and negligence, we are sorry that we did not include all these related works regarding primage studies in China although we aimed to have a comprehensive review of NHP models of human diseases. We sincerely apologize to all those colleagues whose important work is not cited.
中文摘要:

Non-human primates(NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China’s growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China’s life sciences and pharmaceutical industry, and enhance China’s position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China.

英文摘要:

Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China's growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China's life sciences and pharmaceutical industry, and enhance China's position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective to better utilize NHP resources and further foster NHP research in China.

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期刊信息
  • 《动物学研究》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国科学院昆明动物研究所
  • 主编:
  • 地址:昆明市教场东路32号中国科学院昆明动物研究所
  • 邮编:650223
  • 邮箱:zoores@mail.kiz.ac.cn
  • 电话:0871-5199026 5113532
  • 国际标准刊号:ISSN:2095-8137
  • 国内统一刊号:ISSN:53-1229/Q
  • 邮发代号:64-20
  • 获奖情况:
  • 2009年第三届云南省优秀期刊奖,1996年荣获云南省优秀科技期刊二等奖,2000荣获中国科学院优秀期刊三等奖,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),瑞典开放获取期刊指南,中国北大核心期刊(2000版)
  • 被引量:10857