中文摘要：

RNA helicases 涉及几乎 RNA 的每个方面，从抄写到 RNA 腐烂。DExD/H-box helicases 包括最大的 SF2 helicase 总科，它被二个保存象 RecA 一样领域描绘。在最近的年里，这些蛋白质的越来越多的意外功能被发现了。他们不仅在天生的有免疫力的反应而且在象癌症和长期的丙肝一样的疾病起重要作用。在这评论，我们在 SF2 总科的一个成员上总结最近的文学，死了盒子的蛋白质 DDX41。在细菌或病毒的感染以后， DNA 或 cyclic-di-GMP 被释放到房间。在由 BTK kinase 的 Tyr414 的 phosphorylation 以后， DDX41 将充当一个传感器认出侵略者，由类型的正式就职列在后面我干扰素(IFN ) 。在有免疫力的反应以后， DDX41 被 E3 ligase TRIM21 降级，用象 ubiquitination 地点的 DDX41 的 Lys9 和 Lys115。除在天生的免疫的角色以外， DDX41 也与疾病有关。越来越多的在 DDX41 继承了并且获得变化基因从 myelodysplastic 症候群或尖锐 myeloid 白血病(MDS/AML ) 被识别病人。评论在果蝇集中于 DDX41，以及它的相当或相同的事物 Abstrakt，它是重要的因为幸存根本全部上演苍蝇的生命周期。

英文摘要：

RNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay. DExD/H-box hell- cases compdse the largest SF2 helicase superfamily, which are characterized by two conserved RecA-like domains. In recent years, an increasing number of unexpected functions of these proteins have been discovered. They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recant literatures on one member of the SF2 superfamily, the DEAD- box protein DDX41. After bacterial or viral infection, DNA or cyclic-di-GMP is released to cells. After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons （IFN）. After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. Besides the roles in Innate immunity, DDX41 is also related to diseases. An increasing number of both inherited and acquired mutetions in DDX41 gane are identified from myelodysplastic syndrome and/or acute myeloid leukemia （MDS/AML） patients. The review focuses on DDX41, as well as its homolog Abstrakt in Drosophila, which is important for survlval at all stages throughout the life cycle of the fly.