中文摘要：

近年来,多种研究表明CXCR4与CXCR7在肿瘤的发生发展过程中发挥着重要作用,CXCL12-CXCR4/CXCR7趋化因子轴与肿瘤生长和转移的关系引起人们的关注。本文对CXCL12-CXCR4/CXCR7在肿瘤中的表达、促进肿瘤增殖、侵袭转移及与肿瘤干细胞相关性等方面作一综述,提示CXCL12-CXCR4/CXCR7轴可成为抗肿瘤药物治疗的新靶点。

英文摘要：

Recently, a large number of researches have demonstrated that CXCR4 and CXCR7 play a vital role in tumorigenesis. It is well known that CXCL12-CXCR4/CXCR7 axis significantly affects cancer growth and metastasis. Here we discussed the expression of CXCL12-CXCR4/CXCR7 in cancer, and the function of CXCL12-CXCR4/CXCR7 in cancer growth, proliferation and metastasis; moreover, we investigated the effects of CXCL12-CXCR4/CXCR7 in cancer stem cells. In summary, these results indicated CXCL12-CXCR4/CXCR7 may be a novel target for antitumor therapy.