中文摘要：

目的将探索在 apoptosis 相关的蛋白质 Bax， Survivin 和 p53 和致癌作用的分子的机制和胃的癌的前进的表情之间的关系。方法织物微数组和免疫组织化学在这研究被使用。结果在胃的癌症(17.7%,17/96 ) 的 Bax 蛋白质的积极的率是比在邻近的正常粘膜(51%) 的那些显著地低的，肠的组织变形(69.2%) 和发育异常(75%) ， P 【 0.01。在胃的癌症的 Survivin 表示的积极的率(80.6% ， 89/98 ) 在邻近的正常粘膜(3.9%) 比那显著地高， P 【 0.01。在有不同机关转移的肿瘤的 Survivin 表示的积极的率(在淋巴节点转移 86.2% ，肝 100% 和卵巢的 100%) 没有转移(64.3%) ，比在肿瘤统计上高， P 【 0.05。Bax 表示与 Survivin 然而并非与是的 mp53 被相关仔细与 Survivin 表示有关(P 【 0.05 ) 在胃的癌症。Bax， Survivin 和 mp53 的反常表情与胃的癌的肿瘤发生和前进被相关的结论。P53 和 Survivin 基因可以在调整房间 apoptosis 分享类似的机制，并且因为变化， p53 基因可以降低它的下面规定到 Survivin 表示。

英文摘要：

Objective： To explore the relationship between expressions of apoptosis-related protein Bax, Survivin and p53 and the molecular mechanisms of carcinogenesis and progression of gastric carcinoma. Methods： Tissue microarray and immunohistochemistry were used in this study. Results： The positive rate of Bax protein in gastric cancer （17.7%, 17/96） was significantly lower than those in adjacent normal mucosa （51%）, intestinal metaplasia （69.2%） and dysplasia （75%）, P 〈 0.01. The positive rate of Survivin expression in gastric cancer （80.6%, 89/98） was significantly higher than that in adjacent normal mucosa （3.9%）, P 〈 0.01. The positive rates of Survivin expression in tumors with different organ metastases （in lymph node metastasis 86.2%, liver 100% and ovarian 100%） were statistically higher than in tumors without metastasis （64.3%）, P 〈 0.05. Bax expression was correlated with Survivin but not with rap53 that was closely related to Survivin expression （P 〈 0.05） in gastric cancer. Conclusion： The abnormal expressions of Bax, Survivin and rap53 were correlated with the tumorigenesis and progression of gastric carcinoma. P53 and Survivin genes may share the similar mechanism in regulating cell apoptosis, and because of the mutation, p53 gene may lower its down-regulation to Survivin expression.