中文摘要：

间隙连接是相邻细胞间进行物质和信息交换的跨膜蛋白通道结构，是细胞间隙连接通讯的结构基础。间隙连接在多种肿瘤中常发生异常改变，与肿瘤的发生、转移等密切相关。将间隙连接作为靶点设计抗癌新药物，将为肿瘤治疗提供新方向。

英文摘要：

Gap junctions are membrane structures made of intercellular channels that allow directly exchange of material and information between adjacent ceils. It is the structural basis of gap junctional intercellular communication. Gap junction is aberrant frequently in variety of cancers, which relatives with tumor genesis and metastasis. New anti-cancer drugs targeting gap junctions will be a new direction for tumor treatment.