中文摘要：

核因子κB（nuclear factor kappaB，NF-κB）是一种广泛存在于体内多种细胞的核转录因子，与免疫，肿瘤的发生、发展，细胞凋亡的调节以及胚胎发育等有着密切联系，是一种重要的核转录因子。慢性阻塞性肺疾病（chronic obstructive pulmonary diseases，COPD）是一种以气道、肺实质和肺血管的慢性炎症为特征的疾病。NF-κB作为信号转导途径中的枢纽，活化的失调与COPD的发生和发展密切相关，参与COPD的多种发病机制。本文就NF-κB及其在COPD的中的作用作一综述。

英文摘要：

To investigate the role of nuclear factor kappa B（NF-κB） in the pathogenesis of chronic obstructive pulmonary diseases. NF-κB is generally existent in many kinds of cells. It is an important transcription factor which participates in many physiological and pathological processes. As the core of signal transduction pathway, NF-κB closely related to the pathogenesis of chronic obstructive pulmonary diseases.