中文摘要：

尼古丁是一类对人体健康和环境都有很大危害的生物碱,而微生物降解尼古丁是一种非常有效和具有应用潜力的方法,所以对这类微生物代谢途径以及机制的研究具有非常重要的意义,综述了微生物降解尼古丁吡啶代谢途径中几个重要酶的晶体结构以及催化机制的研究进展。

英文摘要：

Nicotine was a kind of alkaloid that had a significant hazard to human health and the environment.The microbial degradation of nicotine was a very effective method and the study of the metabolic pathways of the microbial had very important significance.A general outline of several important enzymes in the pyridine metabolic pathway was presented,and the crystal structure and catalytic mechanism of these enzymes were discussed.