中文摘要：

以D-（-）-酒石酸和D-（-）-酒石酸二异丙基酯为手性源,合成了D-（-）-酒石酸二苄酯和D-（-）-酒石酸二苄胺,这2种单体再分别与对苯二甲酰氯和对苯二异氰酸酯进行聚合,得到聚酯和聚氨酯型手性选择体.将这2种聚合物同时键合到氨丙基硅胶上制得双选择体手性固定相.为了比较分离性能,将两种聚合物分别单独地键合在氨丙基硅胶上,制备了2种单选择体手性固定相.用FTIR、元素分析和NMR对所合成的化合物进行了表征.在相同色谱条件下,用31种手性化合物对3种固定相的手性识别能力进行了评价.研究结果表明,3种固定相均具有较好的手性识别能力,双选择体固定相手性识别能力优于单选择体手性固定相,双选择体手性固定相中的2个选择体之间存在协同作用.

英文摘要：

Two monomers,D-（-）-dibenzyl tartrate and D-（-）-tartaric acid dibenzyl amide,were synthesized with D-（-）-tartaric acid and diisopropyl D-（-）-tartrate as the chiral starting materials. These two monomers were copolymerized,respectively,with terephthaloyl chloride and 1,4-phenylene diisocyanate to yield chiral selectors of polyester and polyurethane. A new biselector CSP was prepared by the simultaneous immobilization of the polyester and the polyurethane on 3-aminopropyl silica gel. For the sake of the comparison with the biselector CSP,two individual phases based on the polyester and the polyurethane were also prepared by the same manner. The monomers,polymers and corresponding CSPs were characterized by FTIR,elemental analysis and NMR. The enantioseparation ability of the CSPs was evaluated towards chiral analytes of different structures under normal and reversed phase modes. The chromatographic data demonstrated the CSPs possess good chiral recognition ability,and the biselector CSP exhibited better chiral recognition ability than the two individual phase CSPs. The reason for the improvement of enantioseparation ability of the biselector CSP might be that the two selectors worked in a coordinative way during chiral recognition.