目的:探讨扩散张量成像(DTI)技术在超急性和急性脑梗死患者中的临床应用价值。方法:对19例超急性脑梗死、22例急性脑梗死患者行常规颅脑MRI及DTI检查。测量梗死灶中心区、边缘区及对侧镜像区的FA、DCavg值,并得到DWI图、DCavg图、FA图、彩色编码FA图及皮质脊髓束图。结果:DWI图、DCavg图、FA图及彩色编码FA图可清楚显示超急性和急性脑梗死病灶。超急性和急性脑梗死组梗死灶中心区FA值分别为(0.481,0.284)×10-4mm2/s,边缘区FA值分别为(0.473,0.306)×10-4mm2/s,急性脑梗死组梗死灶中心区、边缘区FA值与超急性脑梗死组之间差异有统计学意义。超急性和急性脑梗死组梗死灶中心区DCavg值分别为(4.207,4.924)×10-4mm2/s,边缘区DCavg值分别为(5.805,5.420)×10-4mm2/s,急性脑梗死组梗死灶中心区、边缘区与超急性脑梗死组DCavg值之间差异亦有统计学意义。白质纤维束三维重建显示皮质脊髓束为无受累、部分受累、完全受累,其临床肌力分别表现为无减退、治疗后肌力恢复或大部分恢复、无恢复。结论:DTI技术对超急性和急性脑梗死的诊断、治疗及判断预后具有重要的价值。
Objective:To explore the clinical value of diffusion tensor imaging (DTI) in hyperacute and acute cerebral infarction. Methods: Conventional MRI and DTI were performed in 19 patients with hyperacute cerebral infarction and 22 ones with acute cerebral in- farction. FA and DCavg value of eentral, peripheral part of lesions and control regions were measured. DWI map, DCavg map, FA map, color-coded FA map and corticospinal tract (CST) were obtained. Results: DW/map, DCavg map, FA map, color-coded FA map showed lesions of hyperacute and acute cerebral infarction obviously. FA value of eentral parts in hyperacute and acute cerebral infarction were (0.481, 0.284) ~ 10-4nan2/s, respectively. FA value of peripheral parts in hyperacute and acute cerebral infarction were (0.473, 0.306) × 10-4mm2/s, respectivdy. Difference of FA value in central and peripheral parts of lesions between hyperaeute and acute cere- bral infarction were significant. DCavg value of central parts in hyperacute and acute cerebral infarction were (4. 207,4. 924) × 10-4 mm2/s, respectively. DCavg value of peripheral parts in hyperacute and acute cerebral infarction were (5. 805,5.420)× 10-4mm2/s, respectively. Difference of DCavg value in central and peripheral parts of lesions between hyperacute and acute cerebral infarction were significant. CST showed intact, partial disrupted and mostly disrupted, whose myodynamia was normal, recovered after therapy, and not recovered, respectively. Conclusion: DTI has great value for diagnosis, clinical management and prognosis of hyperacute and acute cerebral infarction.