中文摘要：

药物渗透系数是考察复合物膜的药物释放性能的重要参数. 本文以溶解性不同的两种药物扑热息痛和5-氨基水杨酸（5-ASA）为模型药物研究了其在壳聚糖-纤维素硫酸钠聚电解质复合物膜中的渗透性能. 结果表明：壳聚糖-纤维素硫酸钠聚电解质复合物膜的渗透性能与其溶胀性能密切相关；复合物膜中壳聚糖和纤维素硫酸钠的配比、相对分子量和pH值对膜的渗透性能和溶胀性能影响显著，以扑热息痛作为模型药物研究了壳聚糖-纤维素硫酸钠聚电解质复合物膜在模拟胃肠液中对药物的渗透性能. 通过调整该复合物膜的配方，可以使该膜分别实现胃、小肠和结肠定位释药的目的.

英文摘要：

The permeability coefficient is a fundamental parameter for devices exploiting the controlled drug- release behavior of films composed of chitosan and sodium cellulose sulfate （NaCS）. Here, the transport of two model drugs with different solubilities, i.e., paracetamol and 5-aminosalicylic acid （5-ASA）, was studied. The results showed that the permeability of the chitosan/NaCS film was closely related to the swelling properties. In addition, both the permeability and swelling properties of the chitosan/NaCS film were significantly influenced by the mass ratio of chitosan to NaCS, the molecular weights （Mw） of chitosan and NaCS, and the pH value. The permeability of paracetamol across the film was also investigated in simulated gastrointestinal solutions in in vitro tests. The results showed that the films have gastro-, intestine-, and colon-targeting drug-release properties when they are exposed to simulated gastrointestinal fluids in sequence.