中文摘要：

目的 以传统的异色闪烁光密度计（HFP）为参照,评价一种新型黄斑色素密度测量仪MPS1000测量黄斑色素密度（MPOD）的一致性和重复性.方法 方法对比研究.分别采用MPS1000和传统HFP两种仪器测量59例（111只眼）健康受检者黄斑偏心率0.5°注视区的MPOD,并对其中8名受试者在1周后进行重复性测量.两种仪器测量得到的MPOD比较采用配对t检验.结果 MPS1000和传统HFP测量MPOD的平均值分别为0.47±0.15和0.40±0.18,配对t检验显示两种仪器测量值的差异具有统计学意义（t=3.95,P＜0.001）.两种仪器在0.5°注视区的MPOD测量值呈线性正相关（r=0.4,P＜0.001）.Bland-Altman分析显示两种仪器测量值的95％一致性界限为0.07±0.35.MPS1000与传统HFP测量MPOD的重复性系数分别为0.18和0.26.结论 新型MPS1000对MPOD的测量结果重复性较好,比传统HFP的测量结果相对偏高,提示两种方法测量的MPOD值不宜做直接的对比分析.

英文摘要：

Objective To evaluate the measurement of macular pigment optical density （MPOD） by a novel instrument MPS1000 as compared to that measured by the traditional heterochromatic flicker photometer （HFP）.Methods Method-comparative study.MPOD at 0.5° eccentricity was measured simultaneously by the two different instruments in 111 eyes of the 59 healthy subjects.Test-retest variability was evaluated for each instrument over a 1-week period in 8 subjects.Result The mean MPOD levels measured by the MPS 1000 and HFP were 0.40 ± 0.18 and 0.47 ±0.15, respectively, which were statistically significantly different by the paired t-test （t=3.95, P〈0.001）.A positive linear correlation was observed for MPOD at 0.5° eccentricity between the two different instruments （r=0.4, P〈0.001）.The 95% limit of agreement was 0.07±0.35 as shown by Bland-Altman analysis.Inter-sessional repeatability, expressed as a coefficient of repeatability, was 0.26 for HFP and 0.18 for MPS1000.Conclusion MPOD levels measured by MPS1000 were significantly higher as compared to that measured by the traditional HFP, suggesting that it is inappropriate to directly compare the MPOD levels measured by these two methodologies.