中文摘要：

年龄相关性黄斑变性（AMD）是西方国家老年人不可逆盲的首要原因,其发病机制尚未清楚,可能是遗传和环境等多因素共同作用所导致的复杂性疾病.随着分子遗传学和分子生物学研究的逐步深入,已经发现多个AMD易感基因,为促进国内外研究者对AMD的相关性研究,有必要就近年来有关AMD的研究现状予以综述.

英文摘要：

Age related macular degeneration （AMD） is the most common cause of irreversible blindness in the aged population in the western world.AMD is considered to be a multifactorial disease with involvement of both genetic and environmental factors. With the development of molecular biology and molecular genetics,numerous susceptibility genes have been identified.Here we review the recent advances in the genetic studies regarding the AMD susceptibility genes.