中文摘要：

Kashin-Beck disease(KBD)is an endemicchronic osteoarthropathy affecting about2.5millionresidents with over30million at risk in China[1].KBD manifests large defor med joins with muscularastrophy.Its major pathology is a chondrocyte nec-rosis in deep zone of growth plates[2].Etiology ofKBDis still not very clear,but it is supposed thatseleniumdeficiency is likely to be a cofactor in itsdevelopment.Seleniumis unevenly distributed onthe surfaceof the earth and consequently the seleniumconcen-tration varies wide...