中文摘要：

血管新生指从已存在的血管上生长出新的毛细血管的过程。该过程十分复杂,依赖血管内皮细胞、成纤维细胞、巨噬细胞和细胞外基质的相互作用,并受促血管新生分子和抗血管新生分子协同调控。生理条件下,促血管新生分子和抗血管新生分子保持动态平衡;一旦平衡被打破,机体就会出现多种疾病,如肿瘤、多种眼科疾病、

英文摘要：

Angiogenesis is the process of capillary formation from the existing blood vessels,which is regulated by many cytokines. Balance of these cytokines plays an important role in angiogenesis. Unbalance of these cytokines,leading to excessive or insufficient blood vessel,relates to a variety of diseases,such as tumor,ophthalmic diseases and wound healing. Recently,it has been observed that angiogenesis is also involved in Parkinson＇s disease and Alzheimer＇s disease.This review mainly discusses the molecular mechanism of angiogenesis and related diseases,and emphasizes the value of targeting angiogenesis as a strategy to develop drugs for those diseases.