中文摘要：

大量研究表明雌激素具有神经保护作用,但其机制尚不清楚。近年来研究提示,雌激素的神经保护作用与线粒体有着密切联系。线粒体是细胞内能量和活性氧自由基（ROS）的主要来源,对细胞内信号转导、细胞存活与死亡调节等具有十分重要的影响。在生理和病理条件下,雌激素可多方面调节线粒体功能,包括影响ATP与ROS的生成、稳定线粒体膜电位、维护细胞内钙稳态,以及调节线粒体基因和蛋白表达等。本文主要从线粒体角度综述了雌激素神经保护作用及其机制。

英文摘要：

Numerous studies show the neuroprotective effects of estrogen,but the underlying mechanism still remains unclear.Recent studies indicate that mitochondria are critically involved in estrogen-mediated neuroprotection.Mitochondria are the main sources of cellular energy and reactive oxygen species（ROS）,they play an important role in signaling transduction and cellular life-death decisions.Estrogen exerts multiple effects on mitochondria under physiological and/or pathological conditions,these effects may include modulating ATP and ROS production,preserving mitochondria membrane potential,maintaining calcium homeostasis,and regulating mitochondrial gene and protein expression,etc.In this paper,we discussed the neuroprotective effects of estrogen,particularly focused on the underlying mechanisms related to mitochondria.