中文摘要：

目的：观察新型胰岛素增敏剂罗格列酮对单侧输尿管梗阻（UUO）的肾间质损伤的抗氧化保护作用。方法：将雄性SD大鼠随机分成三大组：假手术对照组（Sham组，n=6）、UUO模型组（结扎左侧输尿管制作UUO模型，n=18）、UUO罗格列酮干预组（UUO＋RSG组，n=18）。除Sham组外，其余2组根据不同的观察时间细分为3、7、14d亚组（，n=6）。分别测定大鼠左肾皮质匀浆中脂质过氧化物标志物MDA以及抗氧化酶CAT、SOD含量。结果：与Sham组相比，UUO模型组大鼠梗阻侧肾皮质在3、7、14d时MDA含量分别升高了8．9（P=0．000）、3．5（P=0．000）和0．7倍，而CAT含量分别下降了66．0％、72．6％和83．8％（P=0．000），SOD分别下降了42．0％、50．2％和67．7％（P〈0．005）。与UU0模型组相比，UUO＋RSG组大鼠梗阻侧皮质MDA含量在3、7d时分别减少了80．0％和65．3％（P=0．000），14d时差异不显著；在3、7、14d时CAT分别增加了96．2％、92．1％和102．9％（P〈0．005），SOD分别增加了33．3％、35．1％和55．4％（P〈0．005）。结论：RSG能减少单侧输尿管梗阻侧肾皮质脂质过氧化物的产生，同时增加抗氧化酶的含量，从而改善单侧输尿管梗阻大鼠氧化应激。

英文摘要：

Objective：To investigate the antioxidative effect of rosiglitazone（RSG）, a new insulin sensitizer, on kidney of rats with unilateral ureteral obstruction （UUO）. Methods： Male adult Sprague-Dawley rats were randomly divided into 3 groups： Sham-operated group （n = 6）, UUO model group （UUO model was established by ligating the left ureter, n = 18）, and UUO＋RSG group （UUO model rats were treated with RSG,n= 18）. The latter 2 groups were divided into subgroups according to the times （3 d, 7 d and 14 d） after intervention （n=6）. Malondialdehyde （MDA）, catalase （CAT） and superoxide dismutase （SOD） contents in the homogenized lysate of obstructive renal cortex were determined. Results： Compared with those in Sham-operated group, MDA contents in UUO group increased by 8.9 （P=0. 000）, 3.5 （P=0. 000） and 0.7 times on d 3, d 7 and d 14, respectively, while the contents of CAT and SOD decreased dramatically, with CAT contents reduced by 66.0%, 72.6% and 83.8%, respectively （P=0. 000） and SOD contents reduced by 42.0%, 50.2% and 67.7%, respectively（P〈0. 005）. Compared with those in UUO model group, MDA contents in UUO＋RSG group decreased by 80.0% and 65.3% on d 3 and d 7（P=0. 000）, respectively; no significant difference was found between the 2 contents on d 14; CAT contents were increased by 96.2%, 92.1 % and 102.9%, respectively （P〈0. 005） and SOD content were increased by 33.3%, 35.1% and 55.4 % （P〈0. 005）, respectively. Conclusion： Rosiglitazone can suppress oxidative stress in rats with UUO by reducing lipid peroxidation production and improving antioxidative enzyme contents.