以钯/碳为催化剂,三唑作为易移除导向基团,可实现苯环C(sp2)—H键活化芳基化反应.这是钯/碳作为催化剂催化导向基团促进的C—H活化芳基化反应的首例报道.该反应具有官能团容忍性好,无需银盐氧化剂,导向基团易移除等优点.
A novel protocol for Pd/C catalyzed C(sp~2)—H arylation of benzamides with good functional group compatibility under silver-free conditions by using click-triazoles as a removable directing group has been first developed.