中文摘要：

抗核抗体（ANA）是多种自身免疫病（AID）特别是ANA相关的风湿性疾病（AARD）诊断的重要血清标志物。以HEp-2细胞为基质的间接免疫荧光（IIF）法是ANA检测的重要方法，被美国风湿病学会（ACR）、欧洲自身免疫标准化促进会（EASI）等专业学会推荐为ANA检测的参考方法。2014年8月28日在巴西圣保罗举行的ANA荧光模型国际共识第一次会议上，来自15个国家的66位专家研讨形成ANAHEp-2细胞间接免疫荧光染色模型命名标准化国际共识。2015年9月22日在德国德累斯顿召开的ANA荧光模型国际共识第二次会议上形成了ANA结果报告方式国际共识。认真解读和推广ANAHEp-2细胞间接免疫荧光模型及其结果报告标准化国际共识有助于提高我国ANA检测质量和充分发挥ANA在AID临床诊疗中的价值。

英文摘要：

Antinuclear antibodies （ANA） are important serum markers in the diagnosis of a variety of autoimmune diseases （AID）, especially ANA-associated rheumatic diseases （AARD）. Indirect immunofluorescence assay using HEp-2 cells as substrate is an important method for the detection of ANA, which is considered as the reference method for ANA detection by the American College of Rheumatology （ACR） and the European Autoimmunity Standardization Initiative （EASI）. The first meeting for the International Consensus on Antinuclear antibody Pattern （ICAP） was held in Sao Paulo, Brazil, on August 28, 2014. During the conference, a consensus on the nomenclature of staining patterns observed in the antinuelear antibody （ANA） indirect immunofluorescence test on HEp-2 cells was established by 66 experts representing 15 countries. The second meeting for the ICAP was held in Dresden, Germany, on 22 September 2015, and achieved a consensus regarding the reporting ANA test results. It is helpful to improve the quality of ANA testing in China and give full play to the value of ANA in the clinical diagnosis and treatment of AID, by careful interpretation and promotion of the international consensus on standardizedindirect immunofluorescence nomenclature of antinuclear antibody HEp-2 cell patterns and reporting ANA results.