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中文摘要：
溶瘤腺病毒是治疗肿瘤的一种有效工具,它能选择性地在肿瘤细胞内增殖、裂解肿瘤细胞,而对邻近正常细胞几乎没有影响。利用肿瘤或组织特异性启动子取代控制腺病毒复制必需基因E1A的启动子是构建溶瘤腺病毒的一个策略。现将对这一领域的研究进展进行综述。
英文摘要：
Oncolytic adenoviruses are emerging as apowerful tool in the warfare on cancer. They can selectively replicate in and lead to tumor cell lysis with minimal infectima/replication potential in adjoining non- neoplastic tissue. The efforts to generate selective replication of adenoviruses were achieved by the replacement of adenoviral promoters in particular E1 As with tumor or tissue-specific promote sequences. This article reviewed the advancement in this respect.
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Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated i
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