制备了基于纤维素三(4-三氟甲氧基苯基氨基甲酸酯)衍生物的涂敷型手性固定相(CSP1),并考察了其手性识别能力。研究表明:与商品化Chiralce1OD柱相比,CSP1显示出较低的手性识别能力。CSP1的手性识别能力随流动相中异丙醇含量的降低而升高。与以乙醇为流动相添加剂相比,使用异丙醇为添加剂更有利于对映体的分离。此研究拓展了多糖类衍生物手性固定相的种类。
A coated-type chiral stationary phase (CSP1) based on cellulose tris (4-trifluoromethoxyphenylcarbamate) was prepared and evaluhted for HPLC enantioseparations. Studies revealed that the prepared CSP( CSP1 ) exhibited lower chiral recognition compared to a widely-used, commercially available column, Chiralcel OD. With less 2-propanol added in the mobile phases, better resolutions were obtained on CSP1. Additionally, when ethanol was used instead of 2-propanol as mobile phase additive, poorer enantioseparations were. achieved on CSP1. A new polysaccharide-based CSP for HPLC enantioseparation in this study.