中文摘要：

目的：研究先天性白内障的发生与吸氧浓度之间的关系。方法：将16只孕龄为19d的Wistar大鼠随机分为四组，止血钳钳夹双侧子宫动脉10min。子鼠出生后亦随机分为四组（每组20只），即：空白对照组（吸入正常空气），给予不同浓度氧的A（氧浓度为400mL／L）组、B（氧浓度为600mL／L）组、C组（氧浓度为1000mL／L），吸氧时间为1h／d。检测各鼠晶状体内SOD、MDA含量并利用透射电镜进行观察。结果：随吸氧浓度增加，晶状体中SOD含量减少，MDA含量增加，同时，纤维排列亦改变明显。结论：不同吸氧浓度对新生大鼠晶状体发育可产生不同影响，吸入氧浓度越高，晶状体发生氧化损伤的可能性越大。因此临床上应尽早稳定早产儿及新生儿的生命体征，严密监测用氧指标及用氧情况，使用接近生理水平的较低浓度的氧气以尽量减少不必要的氧疗。

英文摘要：

AIM： To discuss the relation between congenital cataract and oxygen concentrations. METHODS： Sixteen SD rats of nineteen-days gestational age were randomly divided into four groups, all of whose bilateral uterine arteries were clipped with hemostat for 10 minutes. Postnatal rats were also randomly divided into four groups （20 rats per group） with a different oxygen-inhaled concentration in an hour each day： blank group （210mL/L）, group A （400mL/L）, group B （600mL/L） and group C （1000mL/L）. 12 days later, intra-cellular concentrations of SOD, MDA in the lens were measured in each group and the lens of the postnatal rats were observed by transmis-sion electron microscope. RESULTS： With increasing of oxygen-inhaled concentration, MDA increased and SOD decreased. At the same time, there is an obvious change in the form of lens fiber. CONCLUSION： Different oxygen concentrations can produce different results in lens of the rats, which might show a better result under the normal oxygen concentrations compared with pure oxygen. As a result, it＇s better to stabilize vital signs of neonate and preemie, and monitor the usage amount of inhaled oxygen to make sure that the physiological oxygen concentration to be used.