中文摘要：

目的综合评价惊恐障碍与外周血脑源性神经营养因子（BDNF）水平的相关性，探索该类患者外周血BDNF水平特点及相关因素。方法计算机检索ISIWebofscience，Embase，Pubmed和中国期刊网（CNKI）、万方数据资源系统、中国科技期刊数据库（维普数据库），并辅以文献追溯方法，收集1980年1月～2010年8月国内外公开发表的关于惊恐障碍患者外周血BDNF水平的研究文献，采用Revman5．0软件进行Meta分析。结果共纳入3篇文献，累计299名被试者。由于文献数量较少且存在明显的异质性（I2=96％），不进行Meta分析，故仅就文献内容进行了描述。结论目前关于惊恐障碍患者外周血BDNF水平的研究数量尚少。各研究之间结果差异甚大，且在已有研究中存在信息不明确、报告不标准和不全面等问题，需采用公认的测量方法和全面报告结果的准则，进行大样本、前瞻性对照研究。

英文摘要：

Objective To conduct a systematic review of the relationship between peripheral blood levels of brain - derived neurotrophic factor （BDNF） with panic disorder and to explore the characteristics of these patients and related factors. Methods Studies about the peripheral blood level of BDNF published at home and abroad from January 1980 to August 2010 were searched in ISI Web of science, Embase,Pubmed, China journal net （CNKI） , Wanfang Database and Chinese journal of technology database （VIP database）. The method of tracing back was also used to found relevant articles. Revman 5.0 software was used to conduct the Meta analysis. Results 3 articles with a total of 299 participants were involved in analysis. Given the small document quantity and the significant heterogeneity （12 = 96% ） , recta-analysis was not conducted and only the content of the 3 articles were presented. Conclusion Up to now, few studies have reported the peripheral blood level of BDNF in patients with panic disorder and the findings of these studies are of great discrepancy. There are some limitations in existing studies such as indefinite information, un-standard or unilateral report. Further studies should be designed as prospective controlled study carried out in larger samples and use generally accepted method of measurement. The findings should be reported completely.