中文摘要：

背景：随着科学技术的快速发展,表观遗传修饰成为研究热点,其在炎症性肠病中的调控机制部分被揭示,而艾灸能明显改善克罗恩病和溃疡性结肠炎的症状,减轻药物治疗的不良反应,目前其机制尚未阐明。目的：探讨对可能影响炎症性肠病发病的表观遗传学机制,综述艾灸调节对炎症性肠病的效应机制,探讨表观遗传修饰在艾灸对炎症性肠病中的调节作用。方法：电子检索PubMed数据库、中国知网和维普网,英文数据库检索时限2000年1月至2014年12月;中文数据库检索时限1999年1月至2014年12月,检索关键词＂epigenetic;inflammatory bowel disease;crohn’s disease;ulcerative colitis;DNA methylation;histone modification;miRNA;艾灸;炎症性肠病;克罗恩病;溃疡性结肠炎＂。结果与结论：详细阐述了表观遗传修饰与炎症性肠病的发生、发展等方面的相关性,从DNA甲基化、组蛋白修饰和miRNA等方面对炎症性肠病的相关作用靶点及调控机制。艾灸对炎症性肠病的效应机制主要与调节机体免疫相关,而其抗炎的作用机制可能受表观遗传修饰的调节,参与抑炎细胞因子和促炎细胞因子的调控,使机体从慢性炎症状态向免疫保护与耐受转化。

英文摘要：

BACKGROUND： With the rapid development of science and technology, epigenetic modifications become hot, and the mechanism in inflammatory bowel disease has been partly revealed. Moxibustion can significantly improve the patients＇ symptoms of Crohn＇s disease and ulcerative colitis and reduce the side effects of drugs. But its underlying mechanisms have not been elucidated. OBJECTIVE： To explore the possible mechanisms of the epigenetic modification influencing inflammatory bowel diseases, to summarize the effector mechanisms of moxibustion in inflammatory bowel diseases, and to investigate the regulatory role of epigenetic modification in inflammatory bowel diseases by moxibustion.METHODS： A computer-based online research of PubMed, CNKI and VlP databases was performed with the key words of ＂epigenetic; inflammatory bowel disease; Crohn＇s disease; ulcerative colitis; DNA methylation; histone modification; miRNA; moxibustion＂ in Chinese and English. RESULTS AND CONCLUSION： The correlation of epigenetic modification with inflammatory bowel disease occurrence and development is elaborated. The mechanisms in inflammatory bowel disease have been related from DNA methylation, histone modifications and miRNA targets. The mechanism of moxibustion on inflammatory bowel disease is primarily associated with immune regulation, and its anti-inflammatory mechanism may be affected by epigenetic regulation of inflammatory cytokines.