中文摘要：

心血管疾病是严重危害人类健康的头号杀手。随着我国经济的飞速发展，人们生活水平的大幅度提高，饮食结构和生活方式的明显改变以及社会人口老龄化的急剧增加，心血管疾病的危害更加凸显和尖锐。据统计，全球每年约有1700多万人死于心血管疾病；而在我国每年大约有300万人死于心血管疾病，占总死亡原因的41％。

英文摘要：

Mitoehondria are important organelles of energy generation in eukaryocytes and play a pivotal role in cell calcium homeostasis, signal transduction and apoptotic regulation. The possible causes leading to mitoehondrial dys- function include oxidative stress, Ca2 ＊ disorder, reduction of mitoehondrial biosynthesis and mitochondrial DNA mutations, all of which are also closely related to the development of cardiovascular diseases. Understanding the mitochondrial dysfunc- tion and its important role in cardiovascular diseases are very significant for elucidating the mechanisms of cardiovascular diseases.