中文摘要：

对植物内生菌Plantactinospora sp.NEAU-gxj3的次级代谢产物进行了研究,分离得到3个化合物,经1D和2D NMR、MS波谱分析及与文献数据的比较鉴定三个化合物分别为一个新的酰胺类化合物,（2E,7Z）-9-hydroxy-4,6,8-trimethylnona-2,7-dienamide（1）和两个已知化合物,抗生素U-62162（2）和salternamide C（3）。对三个化合物的细胞毒活性实验结果表明化合物2对人白血病细胞株K562、人肺腺癌A549细胞和人肝癌细胞株Hep G2表现出较强的细胞毒活性,其IC_（50）分别为6.8、32μg/m L和19μg/m L。

英文摘要：

A new amide metabolite,（ 2E,7Z）-9-hydroxy-4,6,8-trimethylnona-2,7-dienamide（ 1）,together with two known manumycin-type compounds,antibiotic U-62162（ 2） and salternamide C（ 3） were obtained from the fermentation broth of endophytic Plantactinospora sp. NEAU-gxj3. Their structures were determined on the basis of spectroscopic analysis,including 1D and 2D NMR as well as ESI-MS and comparison with literature data. Bioassay of cytotoxic activities results showed that 2 demonstrated potent cytotoxic activity against human leukemia cell line K562,human lung adenocarcinoma cell line A549 and human liver hepatocellular carcinoma cell line Hep G2 with an IC_（50） value of 6. 8,32 μg /m L and 19 μg / m L,respectively.