中文摘要：

microRNA（简称miRNA）能通过诱导mRNA裂解或抑制mRNA翻译从而在转录后水平调控基因表达，参与细胞发育、增殖、分化、凋亡等一系列重要生物学进程。近期研究发现miRNA对靶基因的异常调控可能参与肿瘤耐药，有望成为重要的肿瘤耐药相关分子标记物及治疗靶点。中药及其有效成分可影响miRNA进而调控相应靶蛋白和靶基因介导肿瘤多药耐药，为中药逆转多药耐药的机制研究提供新思路。

英文摘要：

MicroRNA （miRNA for short） can induce mRNA cleavage or inhibit mRNA translation and regulate gene expression in the post-transcriptional level, which involves cell development, proliferation, differentiation, apoptosis, and a series of important biological processes. Recent studies have found that the abnormal regulation of miRNA＇s target genes may be involved in tumor resistance. And it is expected to become important tumor resistance-associat-ed molecular markers and therapeutic targets. Mechanism of traditional Chinese medicine （TCM） and its active ingre-dients can affect miRNA to regulate target proteins and target genes mediated tumor multidrug resistance. It can pro-vide new ideas for the mechanism of reversing multidrug resistance by TCM.