中文摘要：

目的：探讨3种镁基材料的生物相容性。方法：分别取纯镁（Mg组）、AZ31镁合金（AZ31组）和表面经过微弧氧化处理的AZ31镁合金（MAO组）3种材料，用扫描电镜进行形貌观察后，将人牙周膜干细胞（hPDLSCs）分别接种于3组材料表面进行培养；并观察细胞的增殖曲线（CCK－8实验）以及贴附形态（SEM）。然后将3组材料植入SD大鼠皮下，分别于植入1、2、4、8周处死动物并取材，用场发射扫描电镜和能谱仪观察剩余材料表面的元素变化以及形貌改变；HE染色观察各材料周围组织纤维包裹层厚度及巨噬细胞数量以评价材料所引起的异物反应。结果：3组材料均对hPDLSCs增殖有所抑制，其中以Mg组抑制最大，MAO组最小（P＜0．05），而且hPDLSCs在MAO组表面表现出了更好的贴附状态。3组材料在植入体内后表面元素均发生明显变化，其中以钙、磷元素变化最明显，材料耐腐蚀性以MAO组最强，Mg组最差；其中MAO组在大鼠皮下引起的免疫反应最轻，Mg组最重，各组间差异均有统计学意义（P＜0．05）。结论：经过表面微弧氧化（MAO）处理的镁合金在体内外具有更好的生物相容性以及耐腐蚀性。

英文摘要：

AIM：To supply biocompatibility of three magnesium alloys.METHODS：The surface morphol-ogy of pure Mg （Mg ）,AZ31 Mg alloy（AZ31）and microarc oxidation treated AZ31 alloy （MAO）was examined by SEM.Human periodontal ligament stem cells （hPDLSCs）were cultured on the surface of the samples,the cell prolif-eration was assayed by CCK-8 method and the cell morphology was examined by SEM.Then the samples were trans-planted subcutaneously into the back of SD rats.1,2,4 and 8 w after transplantation,the rats were sacrificed.The surface morphology of the samples was assayed by SEM and energy dispersive spectrometer （EDS）,the foreign body reaction （FBR）was assessed by the reactive capsule thickness and the amount of macrophages.RESULTS：All 3 ma-terials showed inhibitory effects on hPDLSCs proliferation and adhesion,MAO group showed the least influence.In the in vivo test calcium and phosphorus contents on the surface of all materials increased significantly.Corrosion resistance was in the order of MAO〉AZ3 1 ＆gt;Mg.MAO group also demonstrated milder immune reaction than the other 2 groups. CONCLUSION：Microarc oxidation treatment can promote the biocompatibility and corrosion resistance of Mg.