中文摘要：

将N-亚甲基磷酸化壳聚糖（NMPC）引入海藻酸钙水凝胶体系，制备了力学强度和稳定性均优于海藻酸钙和海藻酸／壳聚糖复合水凝胶的可注射型材料．通过正交实验，根据材料的力学性能、浸提液pH值和凝胶化时间的对比分析，确定了各组分质量分数为：海藻酸钠1．50％、碳酸钙0．30％、N-亚甲基磷酸化壳聚糖1．oo％、柠檬酸0．30％．细胞培养和肌内植入试验表明，海藻酸／磷酸化壳聚糖（Alg／NMPC）复合水凝胶具有良好的生物相容性．

英文摘要：

In order to improve the mechanical strength and the stability of the alginate hydrogel, chitosan derivatives, N- methyl phosphate chitosan （NMPC） were introduced into injectable calcium alginate hydrogel system. According to the mechanical properties, extracts pH and gelaton time of the hydrogel, the optimization component content were determined by orthogonal experiment： sodium alginate 1. 50%, calcium carbonate 0.30% , N - methyl phosphate chitosan 1.00%, citric acid 0.30%. Cell culture and intramuscular implantation experiments showed that Alg/NMPC hydrogel had good biocompatibilities.