中文摘要：

为了更精确地对心室组织进行分层,提出了一种线性分层填充方法,利用高分辨率的DT-MRI人体心脏成像数据,基于心肌纤维走向由内向外的旋转角与心室细胞类型之间线性对应关系,对所有心室组织切片,逐片进行层间划分,重建了具有非均匀性细胞分布的三维心室精细解剖结构.然后,将非均匀性单心室细胞计算模型和建立的三维心室解剖结构相结合,进行伪心电图仿真以检验本分层方法的有效性.仿真结果显示伪心电图在QRS波群和T波的形态和间期上与真实心电图吻合,从而证明心室组织分层方法的有效性,可以用于心脏生理、病理相关问题的计算模型仿真研究.

英文摘要：

In order to layer ventricular tissue accurately,a linear layered fill method is proposed in this paper.This method is based on the high-resolution DT-MRI imaging data of human heart and the linear relationship between the rotation angle of the muscle fibers and ventricular cell types,and it has been used to sort the ventricular cells and reconstruct the 3D structure of ventricular tissue for further simulation of heart electrophysiological activities.The pseudo ECG simulation based on the Ten Tusscher model of single ventricular cell and this 3D ventricular structure is used to test the validity of the layering method.The simulation results show that the pseudo-ECG is similar to the real ECG in morphology,the Q-T interval and QRS-wave direction.Therefore the proposed approach for the layering of ventricular tissue is valid,and can be applied to the researches on the modeling and simulation of cardiac physiology and pathology related issues.