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中文摘要：
近年来,多物理尺度建模仿真心电动力学研究已经取得了显著进展.本文介绍当前心脏建模仿真领域中心肌细胞钾离子通道基因突变引起短QT综合征的研究情况.首先从Denis Noble多物理尺度划分的角度介绍了亚细胞与细胞级模型、心肌纤维与组织级模型、心脏器官级模型以及仿真心电图等数学模型,并从量化的角度来分析短QT综合征基因变异在细胞、组织、器官等多层面上对心电功能的影响;然后重点列出了三种短QT综合征亚型近期的研究成果;最后进一步探讨了面向短QT综合征的电生理建模与仿真的研究方向和应用前景.
英文摘要：
M ulti-physical scale modeling for simulating the electrophysiological dynamics of the heart is rapidly evolving and has made significant progress in the last decade. In this paper,w e briefly review the current development of cardiac modeling field w ith a particular focus on the modeling of short QT（ SQT） syndrome arising from gene mutations in cardiac potassium channels. Firstly,w e introduce Denis Noble＇s definition on multi-physical scale modeling of cardiac systems at sub-cellular,cellular,tissue and w hole organ levels. Secondly,w e describe quantities that have been used to characterize the functional impacts of SQT gene mutations on the electrical activity of cardiac systems at cellular,tissue and w hole organ levels. Then w e review up-to-date research results on quantifying the functional impacts of three SQT gene mutations associated w ith potassium channels on the genesis of cardiac arrhythmia that underlie cardiac sudden death. Finally w e outline possible research and application prospects of the electrophysiological modeling and simulation of SQT syndrome in the future.
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