中文摘要：

目的 探讨整合素Mac-1基因缺失对自发肠道腺瘤小鼠ApcMin/＋脂代谢的影响.方法 ApcMin/＋小鼠和Mac-1基因缺失小鼠（Mac-1-/-）扩群获得实验所需数量小鼠,并进行杂交剪尾提取DNA,用PCR法检测小鼠基因型;计数肠道腺瘤数目和体积,并检测血清中总胆固醇（TC）和三酰甘油（TG）的变化.结果 获得Mac-1缺失的自发腺瘤ApcMin/＋;Mac-1-/-小鼠.Mac-1基因缺失后,ApcMin/＋小鼠小肠腺瘤数目和体积减少,血清中TC和TG均下调约40%.结论 Mac-1基因缺失抑制ApcMin/＋小鼠小肠腺瘤生长可能与脂代谢有关.

英文摘要：

Objective To investigate the influence of Mac-1 deficiency on tumor growth and lipid metabolism of spontaneous intestinal adenoma.Methods The ApcMin/＋ mice and Mac-1 knock-out （Mac-1-/-） mice were expanded.The ApcMin/＋ mice were mated with Mac-1-/-mice.The DNA was extracted and genotyped by PCR assay.The tumor number and volume were assessed, and the serum total cholesterol （TC） and triglyceride （TG） were detected.Results The Mac-1 deficiency mice with spontaneous intestinal adenoma were obtained.The tumor number and volume in small intestine were reduced.The serum TG and TC were both reduced by about 40%.Conclusion Mac-1 gene deletion could significantly suppress intestinal adenoma growth, that may correlate with lipid metabolism.