中文摘要：

随着高分子材料学和纳米技术的不断发展,纳米递释系统在药剂学领域的应用潜力逐渐彰显,尤其在基因/药物传递中具有明显的优势。与单一的药物递释系统相比,基因与药物共载递释系统通过增强基因的转染率和逆转多药耐药性等作用,可以明显提高药物的治疗效果。递释系统中引入环境响应性（p H响应、还原响应和光响应等）基团,构建肿瘤内外环境触发释放基因与药物共载递释系统,可以进一步提高抗肿瘤治疗效果。本文综述了近年来环境响应性递释系统在共载基因与药物中的应用进展,分析并总结其在抗肿瘤治疗方面的显著特性。

英文摘要：

With the development of polymeric materials and nanotechnology, the potential application of nanoscaled drug delivery system （NDDS） is gradually manifested in the field of pharmaceutics. Especially, NDDS has the obvious advantages in the delivery of gene or drug. Comparing to the delivery system of single-drug, co-delivery system of gene and drug can significantly improve the therapeutic effects by enhancing transfection efficiency of gene and reversing multidrug resistance, etc. The co-delivery systems of gene and drug, which had the triggered release characteristics in the inner and outer of tumor, could be constructed by introducing the environment-responsive （pH-responsive, redox-responsive and light-responsive, etc） groups into the co-delivery system. The antitumor activity was further improved. In the present paper, the environment- responsive delivery systems in the application of co-delivery gene and drug in recent years were reviewed, and their remarkable properties in the antitumor activity were analyzed and summarized.