重组腺相关病毒(rAAV)载体具有安全性好、免疫原性低、能感染分裂细胞和非分裂细胞、能介导基因长期稳定表达等优点。因此,作为一种基因导人系统,rAAV载体在基因治疗的研究和开发巾越来越受到关注。本文就rAAV载体在基因治疗中的应用作一综述。
Recombinant adeno-associated virus (rAAV) has good safety and low immunogenicity, which may infect both divided and undivided cells and mediate the long-term and stable gene expression. As a gene delivery system, rAAV is paid more and more attentions in study on gene therapy. The application of rAAV in gene therapy is reviewed in this paper.