中文摘要：

在人乳头瘤病毒（human papillomavirus,HPV）次要衣壳蛋白L2的N端和C端,有大量带正电荷的氨基酸残基组成核定位信号（nuclear localization signal,NLS）。细胞的核结构域10（nuclear domain 10,ND10）是细胞周期和病毒生活周期的重要调节者。L2定位到ND10的过程不仅会受到早幼粒细胞白血病蛋白（promyleocytic leukaemia protein,PML）、死亡结构域相关蛋白（deathdomain-associated protein,Daxx）、Sp100核抗原（Sp100 nuclear antigen）等细胞蛋白的影响,也会与L1在ND10发生相互作用。在HPV感染和组装过程中,L2的核定位信号有着重要作用。

英文摘要：

The nuclear localization signal, NLS, which is composed of many amino acids with positive charge residue, is located in both ends of N terminus and C terminus of the human papillomavirus minor capsid protein L2. The nuclear domain 10, ND-10, which is in the cell nucleus, is an important modulator of both cell cycle and virus cyclogeny. The process of the locating of L2 to ND-10, is not only impacted by the cell proteins, such as the promyelocytic leukemia protein, death domain-associated protein Daxx, nuclear antigen Sp 100, but also interacts with L1 in ND-10. The NLS of L2 plays a significant role during the HPV virus assembly course.