中文摘要：

目的：建立吸烟致小鼠肺损伤模型,研究维生素C（VC）和阿司匹林（ASP）联合用药对吸烟致肺损伤的干预作用。方法：将A/J小鼠随机分成5组：正常组、模型组、维生素C组、阿司匹林组、阿司匹林联合维生素C组,并取肺组织进行相关生化指标检测及组织病理观察。结果：模型组与正常组比较,肺组织中的超氧化物歧化酶（SOD）活性和谷胱甘肽（GSH）含量明显降低,丙二醛（MDA）含量则明显升高,同时肺组织病理观察发现有明显的炎症细胞浸润和明显的肺纤维化表现。维生素C组、阿司匹林组以及维生素C联合阿司匹林组与模型组比较,肺组织的SOD活性和GSH含量升高,MDA含量降低,但仅维生素C联合阿司匹林组的数据有统计学意义,且组织病理观察结果显示该组小鼠肺泡结构完整,炎症症状更轻,羟脯氨酸（HYP）含量也明显低于模型组。结论：吸烟能够导致小鼠肺损伤,VC和ASP对吸烟所致的肺损伤有预防作用,且VC和ASP联合用药比单一用药预防效果更佳。

英文摘要：

OBJECTIVE To develop lung damage model induced by cigarette smoking in mice and to observe the protective effects of vitamin C（VC）combined with aspirin（ASP）against cigarette smoking-induced acute lung damage.METHODS A/J mice were assigned to five groups,namely control group,model group,VC group,ASP group and VC combined with ASP group.The mice serum and lung tissue were used for biochemical index determination and histo-pathologic examination.RESULTS In model group,SOD activity and GSH level were decreased and MDA level was increased,moreover,serious inflammatory cells infiltration and pulmonary fibrosis were found in the histo-pathologic examination comparing with control group.SOD activity and GSH level were increased and MDA level was decreased in VC,ASP and VC combined with ASP group comparing with model group.However,only data for VC combined with ASP group were of statistical significance.In addition to that,the structure of the lung alveolar in VC combined with ASP group was intact and no obvious inflammatory cells were observed and hydroxyproline（HYP）content was decreased comparing with model group.CONCLUSION Firstly,animal model of mice lung damage induced by cigarette smoking was successfully established.Secondly,VC use in combination with ASP was more effective than single VC or ASP administration in protection of lung damage induced by cigarette smoking exposure.