中文摘要：

目的：报道异基因造血干细胞移植治愈2例罕见8p11骨髓增殖综合征患者。方法：总结2例8p11骨髓增殖综合征患者的临床、实验室特征及接受异基因造血干细胞移植治疗过程。结果：病例1，双侧颈部淋巴结肿大伴白细胞异常升高，骨髓增生极度活跃，骨髓细胞遗传学示46, XY, （8;13）（p11;q12）。淋巴结组织病理检查结果为外周T细胞淋巴瘤，非特指型。病例2，多发浅表淋巴结肿大伴血常规异常就诊，血白细胞明显升高伴血小板减少，骨髓增生极度活跃，骨髓细胞遗传学示t（8;9）（p11;q32），分子生物学检测CEP110FGFR1融合基因阳性，淋巴结活检为T淋巴母细胞性淋巴瘤。2例患者均行人类白细胞抗原（human leukocyte antigen，HLA）相合同胞异基因造血干细胞移植治疗，无病存活分别为移植后16年和6年。结论：异基因造血干细胞移植是治愈8p11骨髓增殖综合征的有效治疗选择。

英文摘要：

To report 2 rare cases of 8p11 meyloproliferative syndrome cured by allogeneic hematopoietic stem cell transplantation. Methods： The clinical and laboratory features of 2 cases of 8p11 meyloproliferative syndrome were summarized, including the diagnosis and treatment process of allogeneic hematopoietic stem cell transplantation. Results： Patient 1 was presented with bilateral cervical lymphadenopathy and leukocytosis. The pathology of bone marrow showed extremely hyperplasia. The cytogenetic analysis showed a 46, XY, （8;13）（p11;q12） karyotype. The biopsy of the lymph node was peripheral T-cell lymphoma, unspecified. Patient 2 was presented with extensive lymphadenopathy with abnormal hemogram, which was leuekcytosis and thrombpenia. The bone marrow was hypercellular. The cytogenetic analysis on the bone marrow cells showed a translocation of t（8;9）（p11;q32）. The CEP110-FGFR1 fusion transcript was detected by RT-PCR. The biopsy of the lymph node was T lymphoblastic lymphoma. These two patients received human leukocyte antigen （HLA）identical allogeneic hematopoietic stem cell transplantation, remained disease-free and survived 16 years and 6 years after transplantation, respectively. Conclusion： Allogeneic hematopoietic stem cell transplantation is the curative therapy for 8p11 meyloproliferative syndrome.