目的研究维药两色金鸡菊花的化学成分,以期更好地开发利用金鸡菊。方法采用聚酰胺、Sephadex LH-20和ODS柱色谱等分离手段进行化学成分的分离纯化,根据理化性质及波谱数据鉴定其化学结构。结果从两色金鸡菊花醇提取物的乙酸乙酯萃取部分中分离得到8个化合物,分别鉴定为山柰酚-7-O-β-D-吡喃葡萄糖苷(kaempferol-7-O-β-D-glucopyranoside,1)、3',4',7-三羟基黄酮-7-O-β-D-吡喃葡萄糖苷(3',4',7-trihydroxyflavone-7-O-β-D-glucopyranoside,2)、槲皮素-7-O-β-D-吡喃葡萄糖苷(quercetin-7-O-β-D-glucopyranoside,3)、6,7,3',4'-四羟基橙酮(6,7,3',4'-tetrahydroxyaurone,4)、3',5',5-三羟基二氢黄酮-7-O-β-D-吡喃葡萄糖苷(3',5',5-trihydroxyflavanone-7-O-β-D-glucopyranoside,5)、紫铆花素-4'-O-β-D-吡喃葡萄糖苷(butein-4'-O-β-D-glucopyranoside,6)、奥卡宁(okanin,7)、马里苷(marein,8)。结论化合物1~5为首次从金鸡菊属植物中分离得到,化合物6为首次从该两色金鸡菊花中分离得到。
Objective To study the chemical constituents from the capitula of the Coreopsis tinctoria. Methods The chemical constituents were isolated and purified by polyamide, Sephadex LH-20, ODS chro- matography and so on. The structures were elucidated on the basis of physic-chemical properties and spectral data. Results Eight compounds were obtained from the capitula of Coreopsis tinctoria. Their structures were identified as : kaempferol-7-O-β-D-glucopyranoside ( 1 ), 3', 4', 7-trihydroxyflavone-7-O-β-D-glucopyranoside ( 2 ), quercetin-7-O-fl-D-glucopyranoside ( 3 ), 6,7,3', 4'-tetrahydroxyaurone ( 4 ), 3', 5', 5-trihydroxyfla- vanone-7-O-β-D-glucopyranoside( 5 ), butein-4 '-O-β-D-glucopyranoside ( 6 ), okanin ( 7 ) and marein ( 8 ). Conclusions Compounds 1- 5 are isolated from this genus for the first time, compound 6 is isolated from this plant for the first time.