GABAergic 神经原是主要禁止的 interneurons 有力地控制针的 neuronal 网络的函数。在最近的年里,巨大的进步在在背面的针的绳索理解 GABAergic 神经原开发的 transcriptional 控制被取得了。新试验性的途径提供一个相对高的产量方法学习亚群命运决心的分子的规定。我们在在背面的针的绳索的 GABAergic 神经原开发的分子的机制的理解很快正在膨胀。最近的研究定义在针的背面的角在 GABAergic 神经原开发起必要作用的几个抄写因素。这里,我们考察在背面的针的绳索,特别在 homeodomain (HD ) 的进步和包含抄写因素的 basic-helix-loop-helix (bHLH ) 指定 GABAergic 神经原发展的机制的很最近的分析的结果。
GABAergic neurons are the major inhibitory interneurons that powerfully control the function of spinal neuronal networks. In recent years, tremendous progresses have been made in understanding the transcriptional control of GABAergic neuron development in the dorsal spinal cord. New experimental approaches provide a relatively high throughput way to study the molecular regulation of subgroup fate determination. Our understanding of the molecular mechanisms on GABAergic neuron development in the dorsal spinal cord is rapidly expanding. Recent studies have defined several transcription factors that play essential roles in GABAergic neuron development in the spinal dorsal horn. Here, we review results of very recent analyses of the mechanisms that specify the GABAergic neuron development in the dorsal spinal cord, especially the progresses in the homeodomain (HD) and basic-helix-loop-helix (bHLH) containing transcription factors.