中文摘要：

利用真核细胞内泛素-蛋白酶体途径特异性降解蛋白质原理发展而来的靶向泛素化降解蛋白质技术,可通过合成融合蛋白E3或Protacs小分子,特异性敲减某种选定的蛋白底物,有望成为基因或蛋白功能研究的一种新方法,与DNA/RNA水平的基因沉默技术共同在基础和临床医学研究中发挥重要作用。

英文摘要：

Ubiquitin-proteasome pathway(UPP) can degradate specific proteins in eukaryotic cells. Targeting specific proteins for ubiquitination and degradation technique,based the theory of UPP and using certain chimeric E3s or protein-targeting chimeric molecules,can specifically knock down the targeted proteins.It is a promising new method for exploring the functions of genes or proteins and,together with gene-silencing technique,may play an important role in basic and clinical research.