中文摘要：

瞄准：探索肌动朊捆绑蛋白质的角色， fascin 在胰腺的癌症的前进期间。方法：表示人的 fascin-1 的 plasmid 是稳定地 transfected 进胰腺的癌症房间线 MIA PaCa-2。增长，房间周期，活动性，散布，在 fascin-transfected MIA PaCa-2 房间和控制 non-transfected 房间的肌动朊细丝系统的侵略和组织被决定。结果：fascin 的异构的 overexpression 显著地提高了活动性，散布，并且 MIA PaCa-2 房间的侵略。然而， fascin 的 overexpression 在 MIA PaCa-2 房间增长和房间周期上有最小的效果。另外，肌动朊细丝系统的房间形态学和组织清楚地在 fascin overexpressed 房间被改变。当移植了进 BALB/c-nu 老鼠时，胰腺的癌症房间开发了的 fascin-transfected 以稍微更慢的率的稳固的肿瘤，而是这些肿瘤与控制肿瘤比较显示了更多的好攻击的行为。结论：Fascin 支持胰腺的癌症房间移植，侵略并且散布，因此贡献胰腺的癌症房间的好攻击的行为。

英文摘要：

AIM： To explore the role of actin-bundling protein, fascin during the progression of pancreatic cancer,METHODS： The plasmid expressing human fascin-1 was stably transfected into the pancreatic cancer cell line MIA PaCa-2. The proliferation, cell cycle, motility, scattering, invasiveness and organization of the actin filament system in fascin-transfected MIA PaCa-2 cells and control non-transfected cells were determined.RESULTS： Heterogeneous overexpression of fascin markedly enhanced the motility, scattering, and inva-siveness of MIA PaCa-2 cells. However, overexpression of fascin had minimal effect on MIA PaCa-2 cell pro- liferation and cell cycle. In addition, cell morphology and organization of the actin filament system were distinctly altered in fascin overexpressed cells. When transplanted into BALB/c-nu mice, fascin-transfected pancreatic cancer cells developed solid tumors at a slightly slower rate, but these tumors displayed more aggressive behavior in comparison with control tumors.CONCLUSION： Fascin promotes pancreatic cancer cell migration, invasion and scattering, thus contributes to the aggressive behavior of pancreatic cancer cells.