Epstein-Barr病毒(EB病毒)与传染性单核细胞增多症、继发性噬血细胞性淋巴组织细胞增生症和鼻咽癌等相关,是重要的肿瘤相关病毒.EBERs是EB病毒潜伏感染的细胞内数量最多的病毒转录产物,可能在潜伏感染及细胞转化中发挥重要的作用.此文综述了EBER基因变异及EBERs的生物学特性.
Epstein-Barr virus(EBV) is associated with infectious mononucleosis,secondary hemophagocytic lymphohistiocytosis and nasopharyngeal carcinoma.It is one of human tumor-associated virus.EBERs are the most abundant viral transcripts in EBV latent infection cells,and may play an important role in latent infection and cell transformation.The variation of EBERs and the advances on biological function of EBERs are reviewed briefly in this article.